Mitochondria are the most commonly damaged organelles in dopaminergic neurons in Parkinson’s disease (PD) patients. Despite the importance of protecting neuronal mitochondria in PD patients, the detailed mechanisms of mitochondrial dysfunction in the development and pathophysiological progression of PD remain to be elucidated. So, in this blog, I would like to inform of the study, […]
Author: Molly
Degree of Doctor of Naturopathy
Nephrotic syndrome (NS) is a clinical syndrome with various causes that are caused by excessive excretion of protein, typically resulting in the accumulation of fluid in the body (edema), along with decreased blood levels of a protein called albumin and increased blood levels of lipids. It is primarily characterized by severe proteinuria, hypoalbuminemia, and edema. […]
Pulmonary fibrosis is a chronic, progressive, and fatal interstitial lung disease, but there is currently no effective treatment that can improve the prognosis of patients. In this blog, I would like to introduce the research results “Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria crostata” by Sijie Wei et al, which […]
Fucoidan (Fucus vesiculosus), a natural sulfated polysaccharide found in various brown algae, is well known to mediate anti-cancer effects through cell cycle arrest and induction of apoptosis, but the role of the tumor suppressor p53 in the mechanism of action of fucoidan remains unclear. In this blog, I would like to introduce the research,” Induction […]
Morbidity and mortality associated with current treatments for acute promyelocytic leukemia (APL) are high, and despite improvements in patient survival, acute myeloid leukemia is often rapidly progressive, leading to the sudden onset of symptoms. Prompt diagnosis and initiation of treatment are key but remain major clinical concerns. Therefore, developing adjuvant therapies that increase efficacy while […]
As one of the many edible brown algae, Laminaria japonica has seen increased productivity through recent breeding efforts designed to improve commercial cultivation. Fucoidan extracted from Laminaria japonica has been studied for its diverse biological activities. However, brown algae accumulate arsenic (As) during growth, their total arsenic content is relatively higher than that of green […]
The endoplasmic reticulum is an essential organelle for maintaining homeostasis, responsible for the post-translational modification and proper folding of membrane and secretory proteins. However, excessive or sustained endoplasmic reticulum stress is too much for the Unfolded Protein Response (UPR) to handle, and cells ultimately undergo apoptosis. It has been reported that apoptosis can lead to […]
The anti-cancer drug treatment known as chemotherapy can induce a range of side effects, including blood toxicity (bone marrow suppression), gastrointestinal issues such as fever, nausea, vomiting, loss of appetite, constipation, and diarrhea, neurological problems like peripheral neuropathy manifesting as numbness and pain in the hands and feet, allergic responses (hypersensitivity), fatigue, inflammation of the […]
Because triple-negative breast cancer (TNBC) lacks expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, it is difficult to treat effectively, and unfortunately, patients with this subtype of breast cancer have the lowest overall survival rates compared with all other breast cancer types. Currently, the treatment of metastatic TNBC is limited […]
Seaweeds are recognized for their high levels of essential nutrients like carbohydrates, proteins, minerals, and polyunsaturated lipids, along with beneficial compounds that help combat various health issues. This blog post will focus on the seaweed Fucus, specifically to introduce the study, “Phytochemical Constituents and Biological Activities of Fucus spp” by Marcelo D Catarino et al. […]